Translational Neuroscience - Publications by our students

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Our PhD programme is still fairly new - our cohort 1 students only entered final year in September 2019. They are, however, already publishing, including work from the rotation mini-projects they undertook in year 1. Student authors are highlighted in bold. This page will be updated as more publications are submitted.

Published

2020

DNA methylation and brain structure and function across the life course: A systematic review, Emily N.W.Wheater, David Q.Stoye, Simon R.Cox, Joanna M.Wardlaw, Amanda J.Drake, Mark E.Bastin, James P.Boardman, 2020, Neuroscience & Behavioural Reviews 111:133-156 PMCID: PMC7237884 (review)

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical, and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3 (MSS-3), Clancy et al. European Stroke Journal, in press

DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health, Jure Mur, Daniel L. McCartney,  Rosie M. Walker, Archie Campbell, Mairead L. Bermingham, Stewart W. Morris, David J. Porteous, Andrew M. McIntosh, Ian J. Deary,  Kathryn L. Evans, and Riccardo E. Marioni, 2020, Alzheimers Dementia 2020; 6(1): e12026. PMCID: PMC7185210

Translational neuroscience: the state of the nation (a PhD student perspective), Caitlin Davies, Olivia K L Hamilton, Monique Hooley, Tuula E Ritakari, Anna J Stevenson, Emily N W Wheater, 2020, Brain Communications, fcaa038

Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases, Angela C.C. Jochems, Gordon W. Blair, Michael S. Stringer, Michael J. Thrippleton, Una Clancy, Francesca M. Chappell, Rosalind Brown, Daniela Jaime Garcia, Olivia K.L. Hamilton, Alasdair G. Morgan, Ian Marshall, Kirstie Hetherington, Stewart Wiseman, Tom MacGillivray, Maria C. Valdés-Hernández, Fergus N. Doubal, Joanna M. Wardlaw. Stroke 2020;51:1503-1506 PMCID: PMC7185057

2019

An epigenetic predictor of death captures multi-modal measures of brain health, Robert F. Hillary*, Anna J. Stevenson*, Simon R. Cox, Daniel L. McCartney, Sarah E. Harris, Anne Seeboth, Jon Higham, Duncan Sproul, Adele M. Taylor, Paul Redmond, Janie Corley, Alison Pattie, Maria del. C. Valdés Hernández, Susana Muñoz-Maniega, Mark E. Bastin, Joanna M. Wardlaw, Steve Horvath, Craig W. Ritchie, Tara L. Spires-Jones, Andrew M. McIntosh, Kathryn L. Evans, Ian J. Deary & Riccardo E. Marioni, 2019, Molecular Psychiatry ePub Dec2019 PMID: 31796892 * Co-first authors

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life, Anna Stevenson, Daniel McCartney, Robert Hillary, Paul Redmond, Adele Taylor, Qian Zhang, Allan McRae, Tara Spires-Jones, Andrew Mcintosh, Ian Deary, Riccardo Marioni (2019), Translational Psychiatry, 9: 323  PMCID: PMC6883059

Age-related clonal haemopoiesis is associated with increased epigenetic age. Neil A. Robertson, Robert F. Hillary, Daniel L. McCartney, Maria Terradas-Terradas, Jonathan Higham, Duncan Sproul, Ian J. Deary, Kristina Kirschner, Riccardo E. Marioni, Tamir Chandra (2019). Current Biology 29: 786-787. PMID: 31430471

White matter microstructure and its relation to longitudinal measures of depressive symptoms in mid-late life, Shen, X., Adams, M.J., Ritakari, T.E., Cox, S.R., McIntosh, A.M. and Whalley, H.C., 2019,  Biological Psychiatry 86: 759-768 PMID: 31443934

A validated natural language processing algorithm for brain imaging phenotypes from radiology reports in UK electronic health records, Emily Wheater, Grant Mair, Cathie Sudlow, Beatrice Alex, Claire Grover, William Whiteley (2019) BMC Medical Informatics and Decision Making, 19:184 PMCID: PMC6734359

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936, Robert F Hillary, Daniel L McCartney, Sarah E Harris, Anna J Stevenson, Anne Seeboth, Qian Zhang, David C Liewald, Kathryn L Evans, Craig W Ritchie, Elliot M Tucker-Drob, Naomi R Wray, Allan F McRae, Peter M Visscher, Ian J Deary, Riccardo E Marioni (2019), Nature Communications 10:3160 PMCID: PMC6639385

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease, Eleanor K Pickett, Abigail G Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria Fjeldstad, Will Calkin, Leo Murison, Rosemary J Jackson, Makis Tzioras, Anna Stevenson, Marie D'Orange, Monique Hooley, Caitlin Davies, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M Henstridge, Giles Hardingham, Tara Spires-Jones ,(2019), Cell Reports, 29(11):3592-3604 PMCID: PMC6915767

The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study, Weaver NA, Zhao L, Biesbroek JM, Kuijf HJ, Aben HP, Bae H-J, Caballero MAA, Chappell FM, Chen CPLH, Dichigans M, Duering M, Georgakis MK, van der Giessen RS, Gyanwali B, Hamilton OKL, Hilal S, vom Hofe AM, de Kort PLM, Koudstaal PJ, Lam BYK, L J-S, Makin SDJ, Mok VCT, Shi L, Valdes Hernandez MC, Venketasubramanian N, Wardlaw JM, Wollenweber FA, Wong A, Xin X, Meta VCI Map consortium, Biessels GJ., (2019), Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11:310-326, PMCID: PMC6465616

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936, Hamilton OKL, Zhang Q, McRae AF, Walker RM, Morris SW, Redmond P, Campbell A, Murray AD, Porteous DJ, Evans KL, McIntosh AM, Deary IJ,Marioni RE, (2019), International Journal of Obesity, ePub Mar 2019, PMID: 30842548

2018

Application of n-of-1 treatment trials in schizophrenia: systematic review, Marwick KFM*, Stevenson AJ*, Davies C, Lawrie SM, (2018), The British Journal of Psychiatry, 213: 398-403. PMCID: PMC6025794  *Joint first authors.

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease, McCartney DL, Stevenson AJ, Walker RM, Gibson J, Morris SW, Campbell A, Murray AD, Whalley HC, Porteous DJ, McIntosh AM, Evans KL, Deary IJ, Marioni REM (2018),  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring., 10: 429–437 PMCID: PMC6111045

APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease, Tzioras, M.*, Davies, C.*, Newman, A., Jackson, R., and Spires-Jones, T. (2018), Neuropathol Appl Neurobiol., 45: 327-346 * Co-first authors. PMID: 30394574 (Review)

HippoCA3mpal stem cell models expose dysfunctional circuits in schizophrenia, Johnstone M, Fetit R. (2018). Cell Stem Cell, 22(5): 684-697.

Epigenetic prediction of complex traits and death, Daniel L. McCartney*, Robert F. Hillary*, Anna J. Stevenson, Stuart J. Ritchie, Rosie M. Walker, Qian Zhang, Stewart W. Morris, Mairead L. Bermingham, Archie Campbell, Alison D. Murray, Heather C. Whalley, Catharine R. Gale, David J. Porteous, Chris S. Haley, Allan F. McRae, Naomi R. Wray, Peter M. Visscher, Andrew M. McIntosh, Kathryn L. Evans, Ian J. Deary, and Riccardo E. Marioni (2018). Genome Biol. 19: 136 - 147. PMCID: PMC6158884

Complementing tau: new data shows the complement system is involved in degeneration in tauopathies, Caitlin Davies and Tara L Spires-Jones (2018), Neuron 100: 1267 – 1269, PMID: 30571935 (preview article)

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing,  Anna Stevenson; Daniel L McCartney; Sarah E Harris; Adele M Taylor; Paul Redmond; John M Starr; Qian Zhang; Allan F McRae; Naomi R Wray; Tara L Spires-Jones; Barry W McColl; Andrew M McIntosh; Ian J Deary; Riccardo E Marioni (2018).  Clinical Epigenetics 10:159, PMCID: PMC6302523

Epigenetic signatures of stopping and starting smoking, McCartney, D.L., Stevenson, A.J., Hillary, R.F., Walker, R.M., Gibson, J., Morris, S.W., Campbell, A., Murray, A.D., Whalley, H.C., Porteous, D.J., McIntosh, A.M., Evans, K.L., Deary, I.J., Marioni, R.E. (2018). EBioMedicine 37:214-220, PMCID: PMC6286188

Stem Cells to Inform the Neurobiology of Mental Illness. Biomarkers in Psychiatry, Johnstone M, Hillary RF, St. Clair D. (2018).  Curr Top Behav Neurosci [epub ahead of publication] (book chapter)

 

Submitted, currently available on bioRxiv or medRxiv

Associations Between Major Psychiatric Disorder Polygenic Risk Scores and Blood-Based Markers in UK Biobank.  Michael D.E. Sewell,  Xueyi Shen,  Lorena Jiménez-Sánchez,  Amelia J. Edmondson-Stait,  Claire Green,  Mark J. Adams,  Andrew M. McIntosh,  Donald M. Lyall,  Heather C. Whalley,  Stephen M. Lawrie (2020).  MedRxiv.doi.org/10.1101/2020.11.06.20227066

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population. Rebecca A. Madden, Daniel L. McCartney, Rosie M. Walker, Robert F. Hillary, Mairead L. Bermingham, Konrad Rawlik, Stewart W. Morris, Archie Campbell, David J. Porteous, Ian J. Deary, Kathryn L. Evans, Jonathan Hafferty, Andrew M. McIntosh, Riccardo E. Marioni (2019). bioRxiv. doi.org/10.1101/664045.

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability, Anna J. Stevenson, Daniel L. McCartney, Robert F. Hillary, Archie Campbell, Stewart W. Morris, Mairead L. Bermingham, Rosie M. Walker, Kathryn L. Evans, Thibaud S. Boutin, Caroline Hayward, Allan F. McRae, Barry W. McColl, Tara L. Spires-Jones, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni, bioRxiv 802009; doi: doi.org/10.1101/802009

Epigenome-wide analyses identify DNA methylation signatures of dementia risk, Rosie M Walker,  Mairead L Bermingham,  Kadi Vaher, Stewart W Morris,  Andrew D Bretherick,  Yanni Zeng,  VCarmen Amador, Konrad Rawlik, Kalyani Pandya,  Caroline Hayward,  Archie Campbell,  David J Porteous,  Andrew M McIntosh,  Riccardo Marioni,  Kathryn L Evans, medRxiv: doi.org/10.1101/2020.04.06.20055517

Assessment of DNA methylation differences between carriers of APOE ε4 and APOE ε2, Rosie M. Walker, Kadi Vaher,  Mairead L. Bermingham, Stewart W. Morris,  Andrew D. Bretherick,  Yanni Zeng, Konrad Rawlik,  Carmen Amador,  Archie Campbell,  Chris S. Haley,  Caroline Hayward,  David J. Porteous,  Andrew M. McIntosh,  Riccardo E. Marioni, Kathryn L. Evans, bioRxiv: doi.org/10.1101/815035

Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD, Olivia KL Hamilton,  Ellen V Backhouse, Esther Janssen, Angela CC Jochems,  Caragh Maher,  Anna J Stevenson,  Tuula E Ritakari, Lihua Xia,  Ian J Deary,  Joanna M Wardlaw, medRxiv: doi.org/10.1101/2020.02.10.20020628